PLoS ONE 9(10):Įditor: Ryuichi Morishita, Osaka University Graduate School of Medicine, Japan
The possibility of the sorption of examined analytes to sewage sludge particles was discussed based on QSAR.Ĭitation: Jakimska A, Śliwka-Kaszyńska M, Nagórski P, Namieśnik J, Kot-Wasik A (2014) Phototransformation of Amlodipine: Degradation Kinetics and Identification of Its Photoproducts. Only one out of 16 compounds was found in wastewater effluent. Furthermore, the occurrence of amlodipine and its identified degradation products was investigated in environmental waters. Several analytes were formed only in acidic or basic conditions. Fifteen compounds (out of 16 photoproducts) were newly identified and reported here for the first time some of those compounds were formed from the first photoproduct, amlodipine pyridine derivative. As a result sixteen photoproducts were identified, their structures were elucidated and ultimately the transformation pathway was proposed. In the next step, identification of transformation products of amlodipine formed during the exposure to xenon lamp irradiation was performed using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). In all cases degradation of amlodipine followed a pseudo-first-order kinetics. Firstly, the photodegradation kinetic of amlodipine was investigated in two experimental conditions: during the exposure to solar radiation and during the exposure to the light emitted by the xenon lamp. Unfortunately, knowledge about the formation of degradation products is still limited, however, can be very important for the environmental risk assessment. Transformation products may have the same effects to human health and the environment or sometimes they can be more toxic than the parent compound.